2007
| t i t l e | j o u r n a l | a u t h o r |
| Apoptosis prevention in neuronally differentiated PC12 cells, by bcl-2 gene transfection in the non-proliferative and differentiated state, with retention of neuron-specific proteins and blockage of mitocondrion-relayed apoptotic pathway | Gene Therapy & Molecular Biology. 2007 Dec; 11:275-288 | Saitoh Y, Masumoto S, Yanada S, Miwa N |
| Anti-tumor and anti-invasive effects of diverse new macrocyclic lactones, alkylolides and alkenylolides, and their enhancement by hyperthermia | Oncol Reports.2007 Nov;18(5):1257-62 | Tanaka H, Kageyama K, Kusumoto K, Miwa N |
| Anti-tumor and anti-invasive effects of diverse delta-alkyl-lactones: dependence on molecular side-chain length, action period and intracellular uptake | Life Sci. 2007; 24:1851-1855 | Tanaka Y, Kageyama K, Yoshimura Y, Kusumoto K, Asada R, Miwa N |
| Age-dependent telomere-shortening is repressed by phosphorylated alpha-tocopherol together with cellular longevity and intracellular oxidative-stress reduction in human brain microvascular endotheliocytes | J Cell Biochem. 2007 Oct 15;102(3):689-703 | Tanaka Y, Moritoh Y, Miwa N |
| Effects of ethyl-esterization, chain-lengths, unsaturation degrees, and hyperthermia on carcinostatic effect of omega-hydroxylated fatty acids | Experimental Oncology. 2007 Jul; 29(2):106-110 | Kusumoto K, Kageyama K, Matsuda T, Tomura T. T, Tanaka H, Munakata H ,Yazama F, Miwa N |
| Evaluation of the permeability of hair growing ingredient encapsulated PLGA nanospheres to hair follicles and their hair growing effects | Bioorg Med Chem Lett. 2007 Sep 1;17(17):4771-4777 | Tsujimoto H, Hara K, Tsukada Y, Huang C. C.,Kawashima Y,Arakaki M, Mimura H, Miwa N |
| Cytoprotective effect of fruit extracts associated with antioxidant activity against ultraviolet rays | Food Chemistry. 2007 ; 104 (3): 1272-1276 | Kondo S, Yoshikawa H, Miwa N |
| Inhibitory effect of the water-soluble polymer-wrapped derivative of fullerene on UVA-induced melanogenesis via downregulation of tyrosinase expression in human melanocytes and skin tissues | Arch Dermatol Res. 2007 Feb 28; 299:245-257 | Xiao L, Matsubayashi K, Miwa N |
2006
| t i t l e | j o u r n a l | a u t h o r |
| The effect of poly (aspartic acid-co-lactic acid) nanospheres on the lung metastasis of B16BL6 melanoma cells by intravenous administration | Oncology Reports. 2006 Dec;16(6):1215-1220 | Hara K, Tsujimoto H, Huang CC, Kawashima Y, Mimura H, Miwa N |
| Promotive effects of hyperthermia on the inhibition of DNA synthesis in Ehrlich ascites tumor cells by eicosapentaenoic and docosahexaenoic acids | Exp Oncol. 2006 Sep;28(3):203-208 | Tanaka H, Kageyama K, Kimura M, Iwamoto SI, Ueno Y, Asagi K, Asada R, Miwa N |
| Preclinical studies on safety of fullerene upon acute oral administration and evaluation for no mutagenesis | Toxicology. 2006 Aug 1;225(1):48-54 | Mori T, Takada H, Ito S, Matsubayashi K, Miwa N, Sawaguchi T |
| The water-soluble fullerene derivative "Radical Sponge" exerts cytoprotective action against UVA irradiation but not visible-light-catalyzed cytotoxicity in human skin keratinocytes | Bioorg Med Chem Lett. 2006 Mar 15;16(6):1590-159 | 5Xiao L, Takada H, Gan X, Miwa N |
| Transfection of the anti-apoptotic gene bcl-2 inhibits oxidative stress-induced cell injuries through delaying of NF-kB activation | Gene Therapy & Molecular Biology.2006 ; 10 :269-276 | Yanada S , Misumi M, Saitoh Y, Kaneda Y, Miwa N |
| The water-soluble fullerene derivative "Radical Sponge" exerts cytoprotective action against UVA irradiation but not visible-light-catalyzed cytotoxicity in human skin keratinocytes | Bioorg Med Chem Lett. 2006 Mar 15;16(6):1590-1595 | Xiao L, Takada H, Gan X, Miwa N |
| Preventive effects of phosphorylated ascorbate on ultraviolet-B induced apoptotic cell death and DNA strand cleavage through enrichment of intracellular vitamin C in skin epidermal keratinocytes | Free Radic Res. 2006 Feb;40(2):213-221 | Sugimoto M, Okugawa Y, Miwa N |
2005
| t i t l e | j o u r n a l | a u t h o r |
| Antioxidant effects of water-soluble fullerene derivatives against ultraviolet ray or peroxylipid through their action of scavenging the reactive oxygen species in human skin keratinocytes | Biomed Pharmacother. 2005 Aug 5; 59(7):351-358 | Xiao L, Takada H, Maeda K, Haramoto M, Miwa N |
| Hemagglutinating virus of Japan-artificial viral envelope liposome-mediated cotransfer of bag-1 and bcl-2 genes protects hepatic cells against ischemic injury through BAG-1-assisted preferential enhancement of bcl-2 protein expression | Hum Gene Ther. 2005 May;16(5):627-633 | Yanada S, Sasaki M, Takayama S, Kaneda Y, Miwa N |
2004
| t i t l e | j o u r n a l | a u t h o r |
| Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Uncaria sinensis Havil | J Ethnopharmacol. 2004 Dec;95(2-3):127-32 | Na M, Kim YH, Min BS, Bae K, Kamiryo Y, Senoo Y, Yokoo S, Miwa N, Song KS, Seong YH |
| Cytoprotective effect on oxidative stress and inhibitory effect on cellular aging of Terminalia chebula fruit | Phytother Res. 2004 Sep;18(9):737-741 | Na M, Bae K, Kang SS, Min BS, Yoo JK, Kamiryo Y, Senoo Y, Yokoo S, Miwa N |
| Cytoprotection by bcl-2 gene transfer against ischemic liver injuries together with repressed lipid peroxidation and increased ascorbic acid in livers and serum | J Cell Biochem. 2004 Nov 15;93(5):857-870 | Yanada S, Saitoh Y, Kaneda Y, Miwa N |
| Cytoprotection of vascular endotheliocytes by phosphorylated ascorbate through suppression of oxidative stress that is generated immediately after post-anoxic reoxygenation or with alkylhydroperoxides | J Cell Biochem. 2004 Nov 1;93(4):653-663 | Saitoh Y, Miwa N |
| Slow-down of age-dependent telomere shortening is executed in human skin keratinocytes by hormesis-like-effects of trace hydrogen peroxide or by anti-oxidative effects of pro-vitamin C in common concurrently with reduction of intracellular oxidative stress | J Cell Biochem. 2004 Oct 15;93(3):588-597 | Yokoo S, Furumoto K, Hiyama E, Miwa N |
| Preventive effects of a water-soluble derivative of chroman moiety of vitamin E on lipid hydroperoxide-induced cell injuries and DNA cleavages through repressions of oxidative stress in the cytoplasm of human keratinocytes | J Cell Biochem. 2004 Jun 1;92(3):425-435 | Huang Z, Senoh Y, Katoh S, Miwa N |
| Ascorbic acid-2-o-phosphate-6-o-palmitate protecting the human umbilical cord vein endothelial cells against hydrogen peroxide and tert-butyl hydroperoxide induced cytotoxicity | Biomed Pharmacother. 2004 Apr;58(3):205-211 | Fan S, Wei D, Liu J, Xin X, Tong W, Miwa N |
| Enhancement of carcinostatic activity of omega-hydroxy fatty acids by their esterification through increased uptake into tumor cells | Oncology Reports. 2004 Apr;11(4):857-861 | Kusumoto K, Kageyama K, Tanaka H, Kogawa H, Miwa N |
2003
| t i t l e | j o u r n a l | a u t h o r |
| Bcl-2 prevents hypoxia/reoxygenation-induced cell death through suppressed generation of reactive oxygen species and upregulation of Bcl-2 proteins | J Cell Biochem. 2003 Dec 1;90(5):914-924 | Saitoh Y, Ouchida R, Miwa N |
| Repressions of actin assembly and RhoA localization are involved in inhibition of tumor cell motility by lipophilic ascorbyl phosphate | Int J Oncol. 2003 Dec;23(6):1561-1567 | Liu JW, Kayasuga A, Nagao N, Masatsuji-Kato E, Tuzuki T, Miwa N |
| Cytoprotection against ischemia-induced DNA cleavages and cell injuries in the rat liver by pro-vitamin C via hydrolytic conversion into ascorbate | Mol Cell Biochem. 2003 Oct;252(1-2):17-23 | Eguchi M, Miyazaki T, Masatsuji-Kato E, Tsuzuki T, Oribe T, Miwa N |
| Role of MAPK phosphorylation in cytoprotection by pro-vitamin C against oxidative stress-induced injuries in cultured cardiomyoblasts and perfused rat heart | J Cell Biochem. 2003 Oct 1;90(2):219-26 | Eguchi M, Monden K, Miwa N |
| Cytoprotection by pro-vitamin C against ischemic injuries in perfused rat heart together with differential activation of MAP kinase family | J Cell Biochem. 2003 Aug 1;89(5):863-7 | Eguchi M, Fujiwara M, Mizukami Y, Miwa N |
| Anti-apoptotic defense of bcl-2 gene against hydroperoxide-induced cytotoxicity together with suppressed lipid peroxidation, enhanced ascorbate uptake, and upregulated Bcl-2 protein | J Cell Biochem. 2003 May 15;89(2):321-34 | Saitoh Y, Ouchida R, Kayasuga A, Miwa N |
2001
| t i t l e | j o u r n a l | a u t h o r |
| The relationship between UVB screening and cytoprotection by microcorpuscular ZnO orascorbate against DNA photodamage and membrane injuries in keretinocytes by oxidative stress | J Photochem Photobiol B. 2001 Nov 1; 64(1): 27-35 | Hayashi S, Takeshita H, Nagao N, Nikaido O, Miwa N |
| Correlation of DNA synthesis-inhibiting activity and the extent of transmembrane permeation into tumor cells by unsaturated or saturated fatty alcohls of graded chain-length upon hyperthermia | Oncol Rep. 2001 May-Jun; 8(3): 547-51 | Takada Y, Kageyama K, Yamada R, Onoyama Y, Nakajima T, Hosono M, Miwa N |
2000
| t i t l e | j o u r n a l | a u t h o r |
| Cytotoxicity of docosahexaenoic acid and eicosapentaenoic acid in tumor cells and the dependence on binding to serum proteins and incorporation into intracellular lipids | Oncol Rep. 2000 Jan-Feb; 7(1): 79-83 | Kageyama K, Yamada R, Otani S, Onoyama Y, Yano I, Yamaguchi W, Yamaguchi Y, Kogawa H, Nagao N, Miwa N |
| Enhanced invasion of Tax-expressing fibroblasts into the basement membrane is repressed by phosphorylated ascorbate with simultaneous decreased in intracellular oxidative stress and NF-kappaa B activation | Antioxid Redox Signal. 2000 Winter; 2(4): 727-38 | Nagao N, Etoh T, Yamaoka S, Okamoto T, Miwa N |
| Tumor invasion is inhibited by phosphorylated ascorbate via enrichment of intracellular vitamin C and decreasing of oxidative stress | J Cancer Res Clin Oncol. 2000 Sep; 126(9): 551-8 | Nagao N, Nakayama T, Etoh T, saiki I, Miwa N |
| Anti-metastatic effect of an autooxidation-resistant and lipophilic ascorbic acid derivvative through inhibition of tumor invasion | Anticancer Res. 2000 Jan-Feb; 20(1A): 113-8 | Liu JW, Nagao N, Kageyama K, Miwa N |
1999
| t i t l e | j o u r n a l | a u t h o r |
| Antimetastatic and anti-invasive ability of phospho-ascorbyl palmitate through intracellular ascorbate enrichment and the resultant antioxidant action | Oncol Res. 1999; 11(10): 479-87 | Liu JW, Nagao N, Kageyama K, Miwa N |
| Abnormal cell morphology and cytotoxic effect are induced by 6-0-palmitol-ascorbate-2-0-pphosphate, but not by ascorbic acid or hyperthermia alone |
Anticancer Res. 1999 Sep-Oct; 19(5B): 4321-5 |
Kageyama K, Yamada R, Otani S, Hasuma T, Yoshimata T, Seto C, Takada Y, Yamaguchi Y, Kogawa H, Miwa N |
| [Vitamin C: structure-activity correlation and cytoprotective actions through free radical scavenging and extracellular matrix construction] |
Nippon Rinsho. 1999 Oct; 57(10): 2223-9. Review. Japanese. |
Kaneko K, Nagao N, Miwa N |
1998
| t i t l e | j o u r n a l | a u t h o r |
| Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via supression of oxidative stress | Life Sci. 1998; 63(11): 935-48 | Furumoto K, Inoue E, Nagao N, Hiyama E, Miwa N |
| Altered production of the active oxygen species is involved in enhanced cytotoxic action of acylated derivatives of ascorbate to tumor cells |
Biochem Biophys Acta. 1998 Nov 18; 972(2): 144-51 |
Miwa N, Yamazaki H, Nagaoka Y, Kageyama K, Onoyama Y, Matsui-Yuasa I, Otani S, Morisawa S |
1997
| t i t l e | j o u r n a l | a u t h o r |
| Moderately controlled transport of ascorbate into aortic endothelial cells against slowdown of the cell cycle, decreasing of the concentration or increasing of coexistent glucose as compared with dehydroascorbate | Mol Cell Biochem. 1997 Aug; 173(1-2): 43-50 | Saitoh Y, Nagao N, Ouchida R, Yamana T, Kageyama K, Muto N, Miwa N |
| Enhanced protection against peroxidation-induced mortality of aortic endothelial cells by ascorbic acid-2-phosphate abundantly accumulated in the cell as the dephosphorylated form | Free Radic Res. 1997 Jul; 27(1): 97-104 | Fujiwara M, Nagao N, Monden K, Misumi M, Kageyama K, Yamamoto K, Miwa N |
| Cytotoxicity to tumors by alpha, beta-dihydric long-chain fatty alchols isolated from esterolysates of uncytotoxic sheep cutaneous wax: the dependence on the molecular hydrophobicity balance of N-or iso-alkyl moiety bulkiness and two hydroxyl groups |
Cancer Biochem Biophys. 1997 Jun; 15(4): 221-33 |
Miwa N, Nakamura S, Nagao N, Naruse S, Sato Y, kageyama K |
1996
| t i t l e | j o u r n a l | a u t h o r |
| Wool grease-derived alpha-monohydric fatty alchols arecarcinostaticdepending on their branched alkyl moiety bulkiness |
Anticancer Res. 1996 Sep-Oct; 16(5A): 2479-84 |
Miwa N, Nakamura S, Nagao N, Naruse S, Ito H, takada Y, Kageyama K |
| Promotive action of acylated ascorbate on cellular DNA synthesis and grouth at low doses in contrast to inhibitory action at high doses or upon combination with hyperthermia | J Cancer Res Clin Oncol. 1996; 122(1): 41-4 | Kageyama K, Onoyama Y, Otani S, Kimura M, Matsui-Yuasa I, Nagao N, Miwa N |
1995
| t i t l e | j o u r n a l | a u t h o r |
| Differential susceptibility of epidermal keratinocytes and neuroblastoma cells to cytotoxicity of ultraviolet-B light irradiation prevented by the oxygen radical-scavenger ascorbate-2-phosphate but not by ascorbate | Cell Mol Biol Res. 1995; 41(6): 561-7 | Kanatate T, Nagao N, Sugimoto M, Kageyama K, Fujimoto T, Miwa N |
| Enhanced inhibitory effects of hyperthermia combined with ascorbic acid on DNA synthesis in Ehrlic ascites tumor cells grown at a low cell density | Cancer Biochem Biophys. 1995 Jan; 14(4): 273-80 | Kageyama K, Onoyama Y, Otani S, Matsui-Yuasa I, Nagao N, Miwa N |
1994
| t i t l e | j o u r n a l | a u t h o r |
| DNA synthesis inhibition and transmembrane permeation into tumor cells by various dialkyl phthalates upon hyperthermia | Anticancer Res. 1994 Nov-Dec; 14(6B): 2769-72 | Kageyama K, Onoyama Y, Nakajima T, Otani S, Yano I, Hotta H, Matsui-Yuasa I, Kogawa H, Miwa N |
| Inhibition of tumor cell growth by low-boiling-point-saturated fatty acids isolated by molecular distillation and reversed phase liquid chromatography of hydrolysates of uncytotoxic wool grease secreted from sheep sebaceous gland | Cancer Biochem Biophys. 1994 Sep; 14(2): 113-21 | Nakamura S, Nishimura Y, Inagaki K, Miwa N |
1991
| t i t l e | j o u r n a l | a u t h o r |
| Enhanced inhibition of DNA synthesis and release of membrane phospholipids in tumor cells treated with a combination of acylated ascorbate and hyperthermia | Int J Hyperthermia. 1991 Jan-Feb; 7(1): 85-91 | Kageyama K, Onoyama Y, Kimura M, Yamazaki H, Miwa N |
1990
| t i t l e | j o u r n a l | a u t h o r |
| Tumor growth-inhibitory glycoprotein secreted from the mouse brain at terminal stage of the ontogeny: molecular homogeneity and requirement of the retained protein conformation for exhibition of the cytotoxic action | Biochem Biophys Acta. 1990 Jun 20; 1034(3): 309-17 | Miwa N, Mizuno S, Suitani Y |
| [Neonatal brain-derived carcinostatic factor (NBCF)--cytocidal action to neuroblastoma cells and molecular characters as a glycoprotein] | Human Cell. 1990 Jun; 3(2): 137-45. Japanese | Miwa N |
1989
| t i t l e | j o u r n a l | a u t h o r |
| Effect of acylated derivatives of ascorbate on ornithine decarboxylase induction in Ehrlich ascites tumor cells | Biochem Int. 1989 Mar; 18(3): 623-629 | Matui-Yuasa I, Otani S, Morisawa S, Kageyama K, Onoyama Y, Yamazaki H, Miwa N |
1987
| t i t l e | j o u r n a l | a u t h o r |
| Production of tumor growth-inhibiting protein by the neonatal mouse brain: dependence on intracellular glutamine metabolism | J Cell Physiol. 1987 Sep; 132(3): 538-44 | Miwa N, Matsuno T, Mizuno S |
1986
| t i t l e | j o u r n a l | a u t h o r |
| Enhancement of ascorbate cytotoxicity by chelation with ferrous ions through prolonged duration of the action | Anticancer Res. 1986 Sep-Oct; 6(5): 1033-6 | Miwa N, Yamazaki H, Ikari Y |
| Potentiated susceptibility of ascites tumor to acyl derivatives of ascorbate caused by balanced hydrophobicity in the molecule | Exp Cell Biol. 1986 Sep-Oct; 6(5): 245-9 | Miwa N, Yamazaki H |
1985
| t i t l e | j o u r n a l | a u t h o r |
| Inhibition of tumor cell growth by protein factors derived from the developing mouse brain |
J Cancer Res Clin Oncol. 1985; 110(3): 196-202 |
Miwa N, Mizuno S |
1984
| t i t l e | j o u r n a l | a u t h o r |
| Conformational changes in human urokinase induced by a specific reduction of disulfide bond in Cys-194-Cys-222 associated with exhibition of enzymatic activity | Biochem Biophys Acta. 1984 Nov 23; 791(1): 1-8 | Miwa N, Sawada T, Suzuki A |
| A specific disulfide bond associated with the activity of human urokinase. Its topological identification and reductive cleavage followed by kinetic changes in enzymatic reaction and affinity labeling | Eur J Biochem. 1984 May 2; 140(3): 539-45 | Miwa N, Sawada T, Suzuki A |
1983
| t i t l e | j o u r n a l | a u t h o r |
| Differential enhancement of cytotoxicity by combination of the carcinostatic agent benzaldehyde and hyperthermia in simian virus 40-transformed and normal cell lines | Cancer Res. 1983 Sep; 43(9): 4216-20 | Ishida A, Miwa N, Mizuno S |
| Role of pronase-resistant peptide segment of the antitumor protein antibiotics,auromomycin and macromomycin, in stabilizing cytocidal activity of the chromophore moieties to carcinoma cells | J Antibiot(Tokyo). 1983 Jun; 36(6): 715-20 | Miwa N, Mizuno S, Okamoto S |
| The effect of interaction between human urokinase and its competitive inhibitor, N alpha-benzoyl-L-arginine amide, on reduction of a specific SS bond related to enzymatic activity | Biochem Biophys Res Commun. 1983 Apr 29; 112(2): 754-62 | Miwa N, Obata Y, Suzuki A |
1982
| t i t l e | j o u r n a l | a u t h o r |
| Conformations of protein moieties and chromophore-protein interactions in the antitumor antibiotics, macromomycin and auromomycin,characterized by IR and CD spectal analysis | J Antibiot(Tokyo). 1982 Nov; 35(11): 1553-60 | Miwa N |
| Tyrosyl residues of two molecular forms of human urinary urokinase: their ionization mode characterized by spectrophotometric and CD titrations and reactivity with cyanuric fluoride in relation to enzymic activity | Biochem Biophys Res Commun. 1982 Oct 15; 108(3): 1136-43 | Miwa N, Sawada T, Suzuki A |
| Alteration of polypeptide backbone structure as determined by circular dichroic spectal analysis in relation to change of plasminogen activator activity of two forms of human urinary urokinase denatured with guanidine hydrochloride | Chem Pharm Bull(Tokyo). 1982 Oct; 30(10): 3669-78 | Miwa N, Yamashita A, Suzuki A |
| Isoelectic points of two molecular forms of human urinary urokinase determined by density-gradient isoelectric focusing and isotachoelectrophoresis | Chem Pharm Bull(Tokyo). 1982 Apr; 30(4): 1513-6 | Miwa N, Sawada T, Suzuki A |
1981
| t i t l e | j o u r n a l | a u t h o r |
| Comparative studies on two active enzyme forms of human urinary urokinase.Ⅱ. pH-and heat-stabilities of plasminogen activator activity |
Chem Pharm Bull(Tokyo). 1981 Feb; 29(2): 472-5 |
Miwa N, Obata Y, Suzuki A |
| Comparative studies on two active enzyme forms of human urinary urokinase.Ⅰ. Purification by serial column chromatography and homogeneity analysis of molecular weight and isoelectric point | Chem Pharm Bull(Tokyo). 1981 Feb; 29(2): 463-71 | Miwa N, Obata Y, Suzuki A |