doi: 10.1016/j.bbagen.2026.130957.
2)Saitoh Y*, Taniumura Y, Ueda S, Furuhatai T, Takeda M, Okawachi K, Fukukita Y. High-dose ascorbic acid prolongs the suppression of
cell proliferation by enhancing intracellular oxidative stress-induced damage
and inhibits invasion and adhesion in human fibrosarcoma HT-1080 cells. Biochim Biophys Acta Gen Subj. 2026, 1870(4):130908. doi: 10.1016/j.bbagen.2026.130908.
2025年
1)Saitoh Y*, Kanawa S, Nohara T,
Yamaguchi R, Wakita A, Ikeda C, Hamada H. Resveratrol polysaccharide is less
cytotoxicity and inhibits UVA-, UVB-, and tertiary-butyl hydroperoxide-induced
injury in human keratinocytes. Naunyn Schmiedebergs Arch Pharmacol. 2025, 398(6):7377-7387. doi: 10.1007/s00210-024-03749-6
2)Saitoh Y*, Takeda K, Okawachi K, Tanimura Y. High dose of ascorbic acid induces
selective cell growth inhibition and cell death in human gastric signet-ring
cell carcinoma-derived NUGC-4 cells.
2024年
1)Aoshima H*, Mizuno R, Iwatsu Y, Onishi S, Hyodo
S, Ibuki R, Kawagishi H, Saitoh Y. Inhibitory effect of
2-Aza-8-oxohypoxanthine on tyrosinase activity and melanin production. Cosmetics 2024, 11(2), 43. https://doi.org/10.3390/cosmetics11020043
2023年
1)Saitoh Y, Takata Y, Miwa N, Hydrogen-nano-bubble-rich water in bucket/bathtub improves
intractable skin roughness. Hydrogen, 2023, 4(3):456-473. https://www.mdpi.com/2673-4141/4/3/31#
2022年
1) Saitoh Y*, Yonekura
N, Matsuoka D, Matsumoto A. Molecular
hydrogen suppresses Porphyromonas gingivalis lipopolysaccharide-induced
increases in interleukin-1 alpha and interleukin-6 secretion in human gingival
cells. Mol
Cell Biochem. 2022, 477(1):99-104.
2021年
1) Saitoh Y*, Tanaka A, Hyodo S. Protective effects of
polyvinylpyrrolidone-wrapped fullerene against nitric
oxide/peroxynitrite-induced cellular injury in human skin keratinocytes. J Nanosci Nanotechnol. 2021, 21(9):4579-4585. doi: 10.1166/jnn.2021.19279.*Corresponding author
2) Kato S, Saitoh Y, Miwa N. Carcinostatic effects
of alkanoyl ascorbate plus platinum nano-colloid and stabilization of the
esterolytically resultant ascorbate by hydrogen. Human Cell. 2021, 34(2):436-444. doi: 10.1007/s13577-020-00462-3.
3) Saitoh Y*, Kawasaki N, Eguchi N,
Ikeshima M. Combined treatment with dissolved hydrogen molecule and platinum nanocolloid
exerts carcinostatic/carcinocidal effects by increasing hydrogen peroxide
generation and cell death in the human gastric cancer cell line NUGC-4. Free Radic Res. 2021, 55(3):211-220. doi: 10.1080/10715762.2021.1902514.*Corresponding author
4)Saitoh
Y*, Yamaguchi Y, Okada Y. Protective effects of
dissolved molecular hydrogen against hydrogen peroxide-, hydroperoxide-, and
glyoxal-induced injuries to human skin keratinocytes. Mol Cell Biochem. 2021, 476(10):3613-3622.
doi: 10.1007/s11010-021-04189-z. *Corresponding author
2020年
1)
Kato S, Saitoh Y, Miwa N. Hydrogen-bubbled platinum-colloid suppresses
human esophagus- or tongue-carcinoma cells with intracellular platinum-uptake
and the diminished normal-cell mortality.
2) Saitoh Y*, Umezaki
T, Yonekura N, Nakawa A. Resveratrol
potentiates intracellular ascorbic acid enrichment through dehydroascorbic acid
transport and/or its intracellular reduction in HaCaT cells. Mol Cell
Biochem. 2020,467(1-2):57-64. doi:
10.1007/s11010-020-03700-2.
*Corresponding author
2019年
1)
Asada R, Saitoh Y, Miwa N. Effects of hydrogen-rich water
bath on visceral fat and skin blotch, with boiling-resistant hydrogen bubbles. Med Gas Res. 2019 Apr-Jun;9(2):68-73.
2018年
1) Saitoh
Y*, Comments to the article
“Artefacts with ascorbate and other redox-active compounds in cell culture:
epigenetic modifications, and cell killing due to hydrogen peroxide generation
in cell culture media”. Free Radic Res. 2018, 52(9): 910-912. *Corresponding author
2) Saitoh Y*, Nakawa A, Tanabe T, Akiyama T. The influence of
cellular senescence on intracellular vitamin C transport, accumulation, and
function. Mol
Cell Biochem. 2018, 446(1-2):209-219. doi: 10.1007/s11010-018-3287-y. *Corresponding author
3) Hamada H, Shimoda K, Saitoh Y, Doi S, Fujitaka
Y, Ono T, Hamada H, Araki M. Resveratrol oligosaccharide induces mRNA expression for SIRT. Natural product communications
2018, 13(4):455-456.
4)Tanaka Y, Saitoh Y, Miwa N. Electrolytically
generated hydrogen warm water cleanses the keratin-plug-clogged hair-pores and
promotes the capillary blood-streams, more markedly than normal warm water
does. Medical Gas Research 2018, 8(1):12-18.
2017年
1)Ohwada R, Ozeki Y, Saitoh Y*.
High-dose ascorbic acid induces carcinostatic effects through hydrogen peroxide
and superoxide anion radical generation-induced cell death and growth arrest in
human tongue carcinoma cells. Free Radic Res. 2017 Jul-Aug 51(7-8):684-692. doi: 10.1080/10715762.2017.1361533. (http://www.tandfonline.com/doi/full/10.1080/10715762.2017.1361533)
2016年
1)Saitoh Y*, Ohta H, Hyoudou
S. Protective effects of
polyvinylpyrrolidone-wrapped fullerene against intermittent ultraviolet-A
irradiation-induced cell injury in HaCaT cells. J Photochem Photobiol B. 2016, 163:22-29. *Corresponding author
2) Li Q, Tanaka Y, Saitoh Y, Miwa N. Effects of Platinum Nanocolloid in Combination with Gamma Irradiation on Normal Human Esophageal Epithelial Cells. J Nanosci Nanotechnol.2016 16:5345-5352.
3) Saitoh
Y*,
Ikeshima M, Kawasaki N, MasumotoA, Miwa N. Transient generation of hydrogen
peroxide is responsible for carcinostatic effects of hydrogen combined with
platinum nanocolloid, together with increases intracellular ROS, DNA cleavages,
and proportion of G2/M-phase. Free Radical Res. 2016
Apr;50(4):385-95. doi: 10.3109/10715762.2015.1131823.
*Corresponding author
2015年
1)
Saitoh Y*,
Yoshimoto T, Kato S, Miwa N. Combined
treatment with ascorbic acid and a capacitive-resistive electric transfer
hyperthermic apparatus induces synergistically carcinostatic effects on Ehrlich
ascites tumor cell. Exp Oncol. 2015, 37(2):94-99. *Corresponding author
2) Li Q, Tanaka Y, Saitoh Y,
Tanaka H, Miwa N. Carcinostatic
effects of platinum nanocolloid combined with gamma irradiation on human
esophageal squamous cell carcinoma. Life Sci. 2015, 127:106-114. doi:
10.1016/j.lfs.2015.01.028.
3) Kato S, Kato Y, Shibata
H, Saitoh Y, Miwa N. Repressive
effects of oat extracts on intracellular lipid-droplet formation in adipocytes
and a three-dimensional subcutaneous adipose tissue model. Materials science and engineering
C. 2015, C49:269-273.
4) Ishikura H, Ono T, Oki S, Saito Y, Umei N,
Tsumiyama W, Tasaka A, Aihara K, Sato Y, Matsumoto T, Otsuka A. Effect of
stretch on improvement of muscular contractures in rats. J Phys Ther Sci. 2015, 27(9): 2821–2823. doi: 10.1589/jpts.27.2821
2014年
1) Kato S, Aoshima H, Saitoh Y, Miwa N.
Fullerene-C60 derivatives prevent UV-irradiation/TiO2-induced cytotoxicity on
keratinocytes and 3D-skin tissues through antioxidant actions. J
Nanosci Nanotechnol. 2014, 14(5):3285-3291.
2) Asada R, Liao F, Saitoh Y, Miwa N. Photodynamic anti-cancer
effects of fullerene [C60]-PEG complex on fibrosarcomas
preferentially over normal fibroblasts in terms of fullerene uptake and
cytotoxicity. Mol Cell Biochem. 2014, 390(1-2):175-184.
3) Haeiwa
H, Fujita T, Saitoh Y*, Miwa N. Oleic acid promotes adaptability against oxidative stress in 3T3-L1
cells through lipohormesis. Mol Cell Biochem.
2014, 386(1-2):73-83. DOI:
10.1007/s11010-013-1846-9. *Corresponding author
2013年
1) Saitoh Y, Morishita A, Mito S, Tsujiya T, Miwa N. Senescence-induced increases
in intracellular oxidative stress and enhancement of the need for ascorbic
acid in human fibroblasts. Mol Cell Biochem. 2013, 380(1-2):129-141. doi: 10.1007/s11010-013-1666-y.
2) Kato S,
Saitoh Y, Miwa N. Inhibitions
by hydrogen-occluding silica microcluster to melanogenesis in human pigment
cells and tyrosinase reaction. J Nanosci Nanotechnol. 2013,
13(1):52-59.
3) Kato S, Saitoh Y, Miwa N. Repressive
effects of a capacitive-resistive electric transfer (CRet) hyperthermic
apparatus combined with provitamin C on intracellular lipid-droplets formation
in adipocytes. Int J Hyperthermia.
2013, 29(1):30-37.
2012年
1) Saitoh Y, Mizuno H, Xiao L, Hyoudou S, Kokubo K, Miwa N. Polyhydroxylated
fullerene C60(OH) 44 suppresses intracellular lipid
accumulation together with repression of intracellular superoxide anion
radicals and subsequent PPARγ2 expression during spontaneous differentiation of
OP9 preadipocytes into adipocytes. Mol Cell Biochem. 2012, 366(1-2): 191-200.
2) Kato S,
Hokama R, Okayasu H, Saitoh Y, Iwai K, Miwa N. Colloidal platinum in hydrogen-rich water exhibits radical-scavenging
activity and improves blood fluidity. J. Nanosci.
Nanotechnol. 2012, 12(5): 4019-4027.
3) Asada R, Kageyama K, Tanaka H,
Kimura M, Saitoh Y, Miwa N. Carcinostatic effects of diverse ascorbate
derivatives in comparison with aliphatic chain moiety structures: Promotion by
combined hyperthermia and reduced cytotoxicity to normal cells. Oncol Lett. 2012,
3(5):1042-1046.
4) Kato S, Saitoh Y, Iwai K, Miwa N. Hydrogen-rich
electrolyzed warm water represses wrinkle formation against UVA ray together
with type-I collagen production and oxidative-stress diminishment in
fibroblasts and cell-injury prevention in keratinocytes. J
Photochem Photobiol B. 2012, 106(1):24-33.
5) Asada R, Kageyama K, Tanaka H, Saitoh Y, Miwa N. Anti-tumor and
anti-invasive effects of diverse musk-fragrant macrocyclic ketones and
their enhancement by hyperthermia. Mol Med Report 2012, 5(1):148-152.
2011年
1) Xiao L, Aoshima H, Saitoh Y, Miwa N. Highly hydroxylated fullerene localizes at the cytoskeleton and
inhibits oxidative stress in adipocytes and a subcutaneous adipose-tissue
equivalent. Free
Radic Biol Med. 2011, 51(7):1376-1389.
2) Kato S, Asada R, kageyama K, Saitoh Y,
Miwa N. Anticancer effects of 6-O-palmitoyl-ascorbate combined with a capacitive-resistive electric
transfer hyperthermic apparatus as compared with ascorbate in relation to
ascorbyl radical generation. Cytotechnology 2011, 63(4):425-435.
3) Kato S, Aoshima H, Saitoh Y, Miwa N. Fullerene-C60 incorporated in liposome
exerts persistent hydroxyl radical-scavenging activity and cytoprotection in
UVA/B-irradiated keratinocytes. J
Nanosci Nanotechnol. 2011,
11(5):3814-3823.
4) Liao F, Saitoh Y, Miwa N. Anticancer effects
of fullerene [C60] included in polyethylene glycol combined with visible light-irradiation through ROS generation and DNA fragmentation
on fibrosarcoma cells with scarce cytotoxicity to normal fibroblasts. Oncol Res. 2011,
19(5):203-216.
5) Kato S, Matsui H, Saitoh Y, Miwa N. Fish collagen-containing drink is
subcutaneously absorbed and attenuates the UVA-induced tissue-integrity
destruction and DNA damages in 3D-human skin tissue model. J
Funct Foods 2011, 3(1):50-55.
6) Saitoh Y,
Miyanishi A, Mizuno H, Kato S, Aoshima H,
Kokubo K, Miwa N. Super-highly hydroxylated fullerene derivative protects
human keratinocytes from UV-induced cell injuries together with the decreases
in intracellular ROS generation and DNA damages. J Photochem Photobiol B. 2011,
102(1):69-76.
1) Asada R, Kageyama K, Tanaka H, Matsui H, Kimura M, Saitoh
Y, Miwa N. Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum colloid and the combined hyperthermia with apoptosis-like cell
death.
Oncol
Rep. 2010, 24(6):1463-1470.
2) Saitoh Y, Xiao L, Mizuno H, Kato S,
Aoshima H, Taira H, Kokubo K, Miwa N. Novel polyhydroxylated fullerene suppresses intracellular oxidative stress
together with repression of intracellular lipid accumulation during the
differentiation of OP9
preadipocytes into adipocytes. Free Radical Research 2010, 44(9):1072-1081.
3) Xiao L, Aoshima H, Saitoh Y, Miwa N. Fullerene-polyvinylpyrrolidone
clathrate localizes in the cytoplasm to prevent Ultraviolet-A ray-induced
DNA-fragmentation and activation of the transcriptional factor NF-kappa B. J Cell Biochem. 2010,
111(4):955-966.
4) Kato
S, Taira H, Aoshima H, Saitoh Y, Miwa N. Clinical Evaluation of Fullerene-C60
Dissolved in Squalane for Anti-Wrinkle Cosmetics. J Nanosci Nanotechnol. 2010,
10:6769-6774.
5) Kato S,
Aoshima H, Saitoh Y, Miwa N. Defensive effects
of fullerene-C60 dissolved in squalane against the 2, 4-nonadienal- induced
cell injury in human skin keratinocytes HaCaT and wrinkle formation in 3D-human skin tissue
model. J Biomed Nanotechnol.
2010, 6:52-58.
6) Xiao L, Aoshima H, Saitoh
Y, Miwa N. The effect of squalane-dissolved fullerene-C60 on adipogenesis-accompanied
oxidative stress and macrophage activation in a preadipocyte-monocyte co-culture system.
Biomaterials.
2010, 31:5976-5985.
7) Watanabe S, Saitoh
Y, Namba M, Miwa N. Administration with telomeric DNA telomere-like oligonucleotides induces
enhancement of telomerase activity and resistance against oxidative stress in
telomere reverse transcriptase gene-transfected human fibroblasts. Biomed Pharmacother. 2010, 64(8): 565-571.
8) SaitohY, Harata Y, Mizuhashi F, Nakajima
M, Miwa N. Biological safety of neutral-pH hydrogen-enriched electrolyzed water
upon mutagenicity, genotoxicity and subchronic oral toxicity. Toxicol
Ind Health 2010, 26(4):203-216.
9) Kato S, Kikuchi R, Aoshima
H, Saitoh Y, Miwa N. Defensive effects of fullerene-C60/liposome complex
against UVA-induced intracellular reactive oxygen species generation and cell
death in human skin keratinocytes HaCaT, associated with intracellular uptake
and extracellular excretion of fullerene-C60. J
Photochem Photobiol B. 2010,
98(2):144-151.
10) Kato S, Aoshima H, Saitoh Y, Miwa
N. Fullerene-C60/liposome complex: Defensive effects against UVA-induced
damages in skin structure, nucleus and collagen type I/IV fibrils, and the
permeability into human skin tissue. J
Photochem Photobiol B. 2010,
98(1):99-105.
1) Saitoh Y, Yumoto A, Miwa N.
2) Sugimoto M, SaitohY, Ichihashi M, Miwa N.
3) Saitoh Y, Nagai Y, Miwa N.
4) Aoshima H, SaitohY, Ito
S, Yamana S, Miwa N.
5) Saitoh Y, Yoshimura Y, Nakano K, Miwa
N.
growth of human tongue carcinoma cells preferentially over normal cells.
Exp Oncol. 2009,
31(3):156-162.
6) Kato
S, Aoshima H, Saitoh Y, Miwa N.
7) Kato S,
Aoshima H, Saitoh Y, Miwa N.
8) Kato
S, Aoshima H, Saitoh Y, Miwa N.
9) Xiao
L, Kaneyasu K, Saitoh Y, Terashima Y, Kowata Y, Miwa N.
1) Saitoh
Y,
Okayasu H, Xiao L, Harata Y, Miwa N.
1) Saitoh
Y,
Masumoto S, Yanada S, Miwa N.
2) Saitoh
Y,
Fukuoka Y, Nishikimi M, Miwa N. Transfection with glutathione-dependent
dehydroascorbate reductase genes exerts cytoprotective effects against
hydroperoxide-induced cell injury through vitamin C regeneration and
oxidative-stress diminishment. Gene Ther Mol Biol. 2007, 11:143-150.
1) Yanada
S, Misumi M, Saitoh Y, Kaneda Y, Miwa N. Transfection of the
anti-apoptotic gene bcl-2 inhibits
oxidative stress-induced cell injuries through delaying of NF-κB activation. Gene
Ther Mol Biol. 2006, 10:269-276.
2) Yanada
S, Saitoh Y, Kaneda Y, Miwa N.
3) Saitoh
Y and
Miwa N.
4) Saitoh
Y,
Ouchida R, Miwa N.
5) Saitoh
Y,
Ouchida R, Kayasuga A, Miwa N.
6) Nakamura
S, Shibuya M, Saito Y, Nakashima H, Saito F, Higuchi A, Tsubota K.
7) Saitoh
Y,
Nagao N, O'Uchida R, Yamane T, Kageyama K, Muto N, Miwa N.
Original Papers (in Japanese)
総説
1)ビタミンCとその誘導体によるヒト線維芽細胞の老化制御 角尾麻伊、福田大智、齋藤靖和 COSMETIC STAGE (2026年2月号) vol.20,
No.3, 2026, p38-46.
2)複製老化細胞とストレス老化細胞は同質なのか?~老化誘導方法の違いによる表現型と遺伝子発現パターンの差異~ 齋藤靖和 月刊細胞2月号特集「百寿時代」, Vol.57(2), 2025, p36-38.
掲載図のカラー版
3)細胞老化に伴う特徴的な変化からみるSenolysis/Senostaticsの可能性
4)新規素材の美肌・抗老化・抗メタボ効能に関する化粧品・美肌サプリメントとしての研究開発動向~主に水素・白金・フラーレン・プロビタミンC/E・炭酸ガス・天然系抗酸化剤について~
5)細胞死抑制遺伝子bcl-2導入による臓器保護; Bcl-2の抗酸化作用を介した細胞死制御
6)フラーレン誘導体の化粧品としての効能開発と今後の展開?抗酸化作用と細胞死防御効果をベースとして?Fullerene Derivatives: Exploitation of Cosmetic Effects
and Development in the Future ~Based on the Antioxidant Action and Cell-Death
Preventive Effects~
Books
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